Fulfilling a promise to his deceased father, one-time outlaw Jesse Custer returns home to West Texas to take over his dad's church. Jesse's mission, however, becomes twisted when his body is overcome by a cryptic force that unleashes within him a highly unconventional power. Together with hell-raising ex-girlfriend Tulip and Irish vagabond Cassidy, the preacher-in-training embarks on a journey to find God in a world inhabited by holy, hellish, and everything-in-between characters.

In Season 2, after Jesse accidentally discovered that God is absent from Heaven, the three of them set out on a road trip to find Him, all while being hunted by the Saint of Killers, an unstoppable, mythical killer from Hell. The trio’s pursuit led them to New Orleans, where they dodged local gangsters, dangerous agents, and other unimaginable mayhem on their way to uncovering an even bigger secret. Now, with Tulip’s life and Cassidy’s friendship in the balance, Jesse must rely on a mysterious figure from his past in order to save his friends and continue on with his mission.

In Season 3, Jesse Custer’s quest for God takes him back to the place he’s been avoiding his whole life: home. Jesse, Tulip, and Cassidy return to Angelville, the Louisiana Plantation where Jesse was raised, and find old grudges and deadly obligations await them. With the help of his friends — and a few enemies — Jesse will need to escape his past… because the future of the world depends on it.

As our story inches closer to the finale, God's endgame for the universe begins to click into place. Trapped between heavenly prophecies, hellish prisons, and all-out nuclear war, Jesse, Tulip, and Cassidy make their bloody way to the Most High. Whether they can reach God in time — or whether all this carnage is part of His divine plan — will soon be revealed as PREACHER barrels towards the end of the world.