Nat Sirsukmaha-anand M.D. is a neurologist who not only treats his patients’ physical disorders but their love lives as well. Follow along with his case studies on various women with differing backgrounds and personalities, who all have one thing in common - a dire need for romance. One wild night, after spilling secrets about their past failures with the same man they all had been fawning over, the ladies make a bet to see who will marry first. With each episode, Dr. Nat dispenses some sage advice to cure his lovelorn friends’ heart troubles. But it looks like he could use his own advice regarding the guy a dating app listed as his ‘perfect match’!

The ladies return, all at new stages in their lives that will be more complicated than ever! Tata not only has to get used to the role of being a young mother of twins, her husband, Ryu, has been causing her headaches by frequently disappearing, leaving her to cope on her own. What could he be hiding? Tata is also helping her neighbour Lookmai, who has been using her house as her own so that young men who visit won’t learn her actual address. Jane has decided to start a relationship with Saifah, her handsome and young former assistant who has recently become a Youtuber. Kluay is planning a marriage with Ton, her good boyfriend, who works like crazy. Aei has begun to take care of herself with the help of Miriam, a personal trainer who volunteered to take care of both her body and heart. Dr. Nat, the group’s life advisor, continues to develop his relationship with his current partner, Boy.